Rab GTPases in Parkinson's disease: a primer
Antonio Jesús Lara Ordóñez, Rachel Fasiczka, Yahaira Naaldijk, Sabine Hilfiker
Abstract
Parkinson's disease is a prominent and debilitating movement disorder characterized by the death of vulnerable neurons which share a set of structural and physiological properties. Over the recent years, increasing evidence indicates that Rab GTPases can directly as well as indirectly contribute to the cellular alterations leading to PD. Rab GTPases are master regulators of intracellular membrane trafficking events, and alterations in certain membrane trafficking steps can be particularly disruptive to vulnerable neurons. Here, we describe current knowledge on the direct links between altered Rab protein function and PD pathomechanisms.
Topics & Concepts
RabGTPaseCell biologyIntracellularBiologyFunction (biology)Transport proteinPrimer (cosmetics)ChemistryOrganelleGTP-binding protein regulatorsMembrane proteinCellular transport and secretionMicrotubule and mitosis dynamicsParkinson's Disease Mechanisms and Treatments