Targeting EGFR tyrosine kinase: Synthesis, in vitro antitumor evaluation, and molecular modeling studies of benzothiazole-based derivatives
Amal M. Mokhtar, Shahenda M. El‐Messery, Mariam A. Ghaly, Ghada S. Hassan
Topics & Concepts
LapatinibChemistryBenzothiazoleEGFR inhibitorsIn vitroPharmacologyIC50Tyrosine kinaseCancer researchTyrosine-kinase inhibitorEpidermal growth factor receptorBiochemistryCancerTrastuzumabReceptorBiologyBreast cancerInternal medicineMedicineHER2/EGFR in Cancer ResearchQuinazolinone synthesis and applicationsSynthesis and biological activity