The Cancer Dependency Map enables drug mechanism‐of‐action investigations
Francisca Vázquez, Jesse S. Boehm
Abstract
How do small molecules exert their effects in mammalian cells? This seemingly simple question continues to represent one of the fundamental challenges of modern translational science and as such has long been the subject of intense scientific scrutiny. In their recent study, Garnett and colleagues (Gonçalves et al, 2020) demonstrate proof-of-concept for a new way to attack this problem systematically for Oncology drugs, by identifying correlated CRISPR- and drug-killing profiles in the Cancer Dependency Map dataset.
Topics & Concepts
BiologyDependency (UML)ScrutinyComputational biologyDrug discoveryMechanism (biology)DrugAction (physics)CancerCRISPRBioinformaticsComputer scienceGeneticsPharmacologyEpistemologyArtificial intelligencePolitical sciencePhysicsQuantum mechanicsPhilosophyLawGeneCRISPR and Genetic EngineeringInnovative Microfluidic and Catalytic Techniques InnovationComputational Drug Discovery Methods