C(sp<sup>3</sup>)–H cyanation by a formal copper(<scp>iii</scp>) cyanide complex
Jamey K. Bower, Maxwell S. Reese, Ilia M. Mazin, Lina M. Zarnitsa, Andrew D. Cypcar, Curtis E. Moore, Alexander Yu. Sokolov, Shiyu Zhang
Abstract
A formal copper( iii ) cyanide complex and its C–H cyanation reactivity are reported. The redox potentials of substrates, instead of C–H bond dissociation energies, were found to be the key determinant of the rates of PCET.
Topics & Concepts
CyanationCyanideChemistryCopperStereochemistryMedicinal chemistryOrganic chemistryCatalysisCatalytic C–H Functionalization MethodsMetal-Catalyzed Oxygenation MechanismsSynthesis and Catalytic Reactions