Cocrystals of regorafenib with dicarboxylic acids: synthesis, characterization and property evaluation
Jun-Long Jia, Xia-Lin Dai, Hao-Jie Che, Meng-Ting Li, Xiaomei Zhuang, Tong‐Bu Lu, Jia‐Mei Chen
Abstract
Three cocrystals of regorafenib were synthesized, and two of them demonstrate significantly improved solubility and tabletability without compromising physicochemical stability.
Topics & Concepts
RegorafenibCharacterization (materials science)Property (philosophy)Materials scienceChemistryCombinatorial chemistryNanotechnologyMedicinePhilosophyColorectal cancerInternal medicineCancerEpistemologyCrystallography and molecular interactionsCrystallization and Solubility StudiesComputational Drug Discovery Methods