Anti-PEG IgE in anaphylaxis associated with polyethylene glycol
Zhao‐Hua Zhou, Cosby A. Stone, Baruch D. Jakubovic, Elizabeth J Phillips, Gordon Sussman, JuMe Park, Uyen Hoang, Susan L Kirshner, Robert Levin, Steven Kozlowski
Abstract
Polyethylene glycol (PEG) has been used in a wide range of medical and pharmaceutical products as an active ingredient or excipient. In addition, an increasing number of PEG-modified (PEGylated) therapeutic proteins and drugs are being developed and approved for marketing.1 The covalent attachment of PEG to a drug or therapeutic protein increases hydrodynamic size and can increase half-life.
Topics & Concepts
Polyethylene glycolAnaphylaxisPEGylationPEG ratioMedicineAllergyExcipientPharmacologyImmunoglobulin EAdverse effectActive ingredientImmunologyChemistryAntibodyBiochemistryFinanceEconomicsDrug-Induced Adverse ReactionsContact Dermatitis and AllergiesFood Allergy and Anaphylaxis Research