<i>Bacillus subtilis</i> as a host for natural product discovery and engineering of biosynthetic gene clusters
Hanne Put, Hans Gerstmans, Hanne Vande Capelle, Maarten Fauvart, Jan Michiels, Joleen Masschelein
Abstract
This review explores the use of Bacillus as a heterologous host for natural product discovery and engineering, highlighting its unique traits, successful natural product examples and available genetic engineering tools.
Topics & Concepts
Natural productBacillus subtilisComputational biologyHeterologous expressionHeterologousIdentification (biology)GeneDrug discoveryBiologyHost (biology)BioinformaticsGeneticsBiochemistryBacteriaRecombinant DNAEcologyMicrobial Natural Products and BiosynthesisMicrobial Metabolism and ApplicationsMicrobial Metabolic Engineering and Bioproduction