High childhood serum triglyceride concentrations associate with hepatocellular adenoma development in patients with glycogen storage disease type Ia
Martijn P. D. Haring, Fabian Peeks, Maaike H. Oosterveer, Martijn C.G.J. Brouwers, Carla E. M. Hollak, Mirian C. H. Janssen, Janneke G. Langendonk, Alexander J. Rennings, Margreet A.E.M. Wagenmakers, Henkjan J. Verkade, Terry G. J. Derks, Vincent E. de Meijer
Abstract
Background & Aims: genotype, and serum triglyceride concentration (TG). Methods: 500 mg/dl). Results: = 0.028). Conclusions: genotype. Lay summary: Glycogen storage disease type Ia (GSDIa) is a rare, inherited metabolic disease that can be complicated by liver tumours (hepatocellular adenomas), which in turn may cause bleeding or progress to liver cancer. Risk factors associated with hepatocellular adenoma formation in patients with GSDIa are largely unknown. In our study, we found that high serum triglyceride concentrations during childhood, but not specific genetic variants, were associated with increased risk of hepatocellular adenoma diagnosis later in life.