ECM-derived biomaterials for regulating tissue multicellularity and maturation
Ali Smandri, Maimonah Eissa Al-Masawa, Min Hwei Ng, Mh Busra Fauzi
Abstract
counterparts. In this review, we highlight the use of extracellular matrix (ECM)-derived biomaterials in providing stem cell niche-mimicking microenvironment capable of preserving stem cell long-term potency and inducing spatial and region-specific differentiation. We also examine the maturation of different 3D models, including organoids, encapsulated in ECM biomaterials and provide looking-forward perspectives on employing ECM biomaterials in building more innovative, transplantable, and functional organs.
Topics & Concepts
Multicellular organismTissue engineeringChemistryNanotechnologyCell biologyBiologyMaterials scienceCellBiochemistryGeneticsTissue Engineering and Regenerative MedicineElectrospun Nanofibers in Biomedical ApplicationsRenal and related cancers