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LncRNA MALAT1 induces the dysfunction of β cells via reducing the histone acetylation of the PDX-1 promoter in type 1 diabetes

Haixia Ding, Fujun Wang, Xuelian Shi, Hongfang Ma, Yaping Du, Lin Hou, Na Xing

2020Experimental and Molecular Pathology74 citationsDOI

Topics & Concepts

Gene knockdownAcetylationHistoneMALAT1Histone H3Molecular biologyBiologyChemistryEpigeneticsInsulinEndocrinologyCell cultureCell biologyCancer researchDownregulation and upregulationBiochemistryGeneLong non-coding RNAGeneticsPancreatic function and diabetesDiabetes and associated disordersCancer-related molecular mechanisms research
LncRNA MALAT1 induces the dysfunction of β cells via reducing the histone acetylation of the PDX-1 promoter in type 1 diabetes | Litcius