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Design and synthesis of β-carboline linked aryl sulfonyl piperazine derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability

Kesari Lakshmi Manasa, Sowjanya Thatikonda, Dilep Kumar Sigalapalli, Arpita Sagar, Gaddam Kiranmai, Arunasree M. Kalle, Mallika Alvala, Chandraiah Godugu, Narayana Nagesh, Bathini Nagendra Babu

2020Bioorganic Chemistry28 citationsDOI

Topics & Concepts

ChemistryTopoisomeraseSulfonylCytotoxicityApoptosisStereochemistryDocking (animal)Cell cultureDNAArylGrowth inhibitionPiperazineBiochemistryPharmacologyIn vitroBiologyAlkylOrganic chemistryMedicineNursingGeneticsSynthesis and bioactivity of alkaloidsCancer therapeutics and mechanismsSynthesis and Biological Evaluation
Design and synthesis of β-carboline linked aryl sulfonyl piperazine derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability | Litcius