The role of ligand endocytosis in notch signalling
Ekaterina Seib, Thomas Klein
Abstract
The Notch signalling receptor is a mechanoreceptor that is activated by force. This force elicits a conformational change in Notch that results in the release of its intracellular domain into the cytosol by two consecutive proteolytic cleavages. In most cases, the force is generated by pulling of the ligands on the receptor upon their endocytosis. In this review, we summarise recent work that shed a more detailed light on the role of endocytosis during ligand-dependent Notch activation and discuss the role of ubiquitylation of the ligands during this process.
Topics & Concepts
EndocytosisCell biologyBiologyNotch signaling pathwayCytosolUbiquitinReceptorIntracellularSignallingReceptor-mediated endocytosisLigand (biochemistry)InternalizationBiophysicsSignal transductionBiochemistryGeneEnzymeUbiquitin and proteasome pathwaysCell Adhesion Molecules ResearchDevelopmental Biology and Gene Regulation