Design, synthesis and biological evaluation of new eugenol derivatives containing 1,3,4-oxadiazole as novel inhibitors of thymidylate synthase
Mohammad Mahboob Alam, Serag Eldin I. Elbehairi, Ali A. Shati, Rania A. Hussien, Mohammad Y. Alfaifi, Azizah M. Malebari, Mohammad Asad, Ahmed A. Elhenawy, Abdullah M. Asiri, Ali Mahzari, Reem F. Alshehri, Syed Nazreen
Abstract
We report the preparation and cytotoxicity of two new eugenol derivatives that contain 1,3,4-oxadiazole, as novel inhibitors of thymidylate synthase; these derivatives are shown to be promising chemotherapeutic agents.
Topics & Concepts
Thymidylate synthaseChemistryCytotoxicityOxadiazoleEugenolBiochemistryCombinatorial chemistryIn vitroOrganic chemistryCancerFluorouracilMedicineInternal medicineBiochemical and Molecular ResearchColorectal Cancer Treatments and StudiesSynthesis and biological activity