An efficient electrochemical sensor based on CeVO<sub>4</sub>-CuWO<sub>4</sub>nanocomposite for methyldopa
Hadi Halakoei, Masoumeh Ghalkhani, Ali Sobhani‐Nasab, Mehdi Rahimi‐Nasrabadi
Abstract
Abstract A novel modified electrode based on cerium vanadate and copper tungstate (CeVO 4 -CuWO 4 ) nanocomposite was prepared as a sensitive sensor for the methyldopa. The prepared nanocomposite was characterized by x-ray diffraction (XRD), energy dispersive x-ray spectroscope (EDX), Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM) methods. The cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques were applied for the evaluation of the electrochemical performance of the sensor. The enhanced active surface area, electro-catalytic activity, and expedient conductivity provided by the CeVO 4 -CuWO 4 nanocomposite led to the peak current increment with a well-resolved anodic peak for methyldopa in the presence of potential interferences. The CeVO 4 -CuWO 4 nanocomposite-based modified electrode successfully measured methyldopa over a wide concentration range of 0.02–400 μ M with the low limit of detection (LOD) of 0.006 μ M. The findings of the methyldopa sensing in human serum samples verified the proper efficiency of the proposed sensor.