The Polar <i>Legionella</i> Icm/Dot T4SS Establishes Distinct Contact Sites with the Pathogen Vacuole Membrane
Desirée Böck, Dario Hüsler, Bernhard Steiner, João M. Medeiros, Amanda Welin, Katarzyna A. Radomska, Wolf‐Dietrich Hardt, Martin Pilhofer, Hubert Hilbi
Abstract
Legionnaires’ disease is a life-threatening pneumonia, which is characterized by high fever, coughing, shortness of breath, muscle pains, and headaches. The disease is caused by the amoeba-resistant bacterium L. pneumophila found in various soil and aquatic environments and is transmitted to humans via the inhalation of small bacteria-containing droplets.
Topics & Concepts
Legionella pneumophilaVacuoleEffectorSecretionMicrobiologyBiologyLegionellaCell biologyPhagosomeFlagellumBacterial outer membranePathogenBacteriaIntracellularBiochemistryCytoplasmEscherichia coliGeneticsGeneLegionella and Acanthamoeba researchBacterial biofilms and quorum sensingNeutrophil, Myeloperoxidase and Oxidative Mechanisms