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Development of phenolic Mannich bases as α-glucosidase and aldose reductase inhibitors: In vitro and in silico approaches for managing diabetes mellitus and its complications

Feyzi Sinan Tokalı, Yeliz Demir, Şeyma Ateşoğlu, Pelin Tokalı, Halil Şenol

2025Bioorganic & Medicinal Chemistry39 citationsDOI

Topics & Concepts

Aldose reductaseChemistryIn silicoAldehyde ReductaseAldose reductase inhibitorIn vitroDiabetes mellitusEnzymeBiochemistryAldoseEnzyme inhibitorPharmacologyStereochemistryGlycosideEndocrinologyMedicineGeneAldose Reductase and TaurineEnzyme function and inhibitionBiochemical Acid Research Studies
Development of phenolic Mannich bases as α-glucosidase and aldose reductase inhibitors: In vitro and in silico approaches for managing diabetes mellitus and its complications | Litcius