A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c
Hirofumi Zempo, Su‐Jeong Kim, Noriyuki Fuku, Yuichiro Nishida, Yasuki Higaki, Junxiang Wan, Kelvin Yen, Brendan Miller, Roberto Vicinanza, Eri Miyamoto‐Mikami, Hiroshi Kumagai, Hisashi Naıto, Jialin Xiao, Hemal H. Mehta, Changhan Lee, Megumi Hara, Yesha Patel, Veronica Wendy Setiawan, Timothy M. Moore, Andrea L. Hevener, Yoichi Sutoh, Atsushi Shimizu, Kaname Kojima, Kengo Kinoshita, Yasumichi Arai, Nobuyoshi Hirose, Seiji Maeda, Keitaro Tanaka, Pinchas Cohen
Abstract
. Thus, the m.1382A>C polymorphism is associated with susceptibility to T2D in men, possibly interacting with exercise, and contributing to the risk of T2D in sedentary males by reducing the activity of MOTS-c.
Topics & Concepts
Mitochondrial DNAAlleleType 2 diabetesGeneticsBiologyPolymorphism (computer science)Type 2 Diabetes MellitusMitochondrionEndocrinologyInternal medicineGeneDiabetes mellitusMedicineAdipose Tissue and MetabolismGDF15 and Related BiomarkersMitochondrial Function and Pathology