Introducing Savie: A Biodegradable Surfactant Enabling Chemo- and Biocatalysis and Related Reactions in Recyclable Water
Joseph R. A. Kincaid, Madison J. Wong, Nnamdi Akporji, Fabrice Gallou, David M. Fialho, Bruce H. Lipshutz
Abstract
Savie is a biodegradable surfactant derived from vitamin E and polysarcosine (PSar) developed for use in organic synthesis in recyclable water. This includes homogeneous catalysis (including examples employing only ppm levels of catalyst), heterogeneous catalysis, and biocatalytic transformations, including a multistep chemoenzymatic sequence. Use of Savie frequently leads to significantly higher yields than do conventional surfactants, while obviating the need for waste-generating organic solvents.
Topics & Concepts
ChemistryBiocatalysisCatalysisPulmonary surfactantHomogeneousOrganic chemistryHomogeneous catalysisOrganic synthesisHeterogeneous catalysisCombinatorial chemistryIonic liquidBiochemistryThermodynamicsPhysicsChemistry and Chemical EngineeringEnzyme Catalysis and ImmobilizationPharmaceutical and Antibiotic Environmental Impacts