Uniting the divergent Wolfram syndrome–linked proteins WFS1 and CISD2 as modulators of Ca<sup>2+</sup>signaling
Jens Loncke, Tim Vervliet, Jan B. Parys, Allen Kaasik, Geert Bultynck
Abstract
channels, it is thought that they influence the activity of these transport systems in cells. Together, the studies reviewed here provide a better understanding of the pathogenesis and the severe disease burden of WS and may contribute to the development of therapeutics.
Topics & Concepts
Wolfram syndromeSignaling proteinsSignal transductionCell biologyCalcium signalingBiologyCalciumChemistryBiochemistryGeneOrganic chemistryEndoplasmic Reticulum Stress and DiseaseMetalloenzymes and iron-sulfur proteinsGenetics and Neurodevelopmental Disorders