Aloin promotes cell apoptosis by targeting HMGB1-TLR4-ERK axis in human melanoma cells
Li Pan, Kai Ren, Yin Liang, Ji Kai Liu, Zhuo Liang, Yongfeng Zhang
Abstract
. Furthermore, HMGB1 release was significantly inhibited in melanoma cancer cells treated with ALO. Knockdown of HMGB1 could enhance melanoma cell death that is induced by ALO treatment. Moreover, HMGB1 facilitated ALO mediated melanoma cell apoptosis by binding to its receptor, Toll-like receptor 4 and activating extracellular regulated protein kinases (ERK) signal pathway. Altogether, our study demonstrated that ALO plays an important role in promoting apoptosis of melanoma cells by inhibiting HMGB1 release and activation of downstream ERK signal pathway.
Topics & Concepts
HMGB1ApoptosisMAPK/ERK pathwayMelanomaCancer researchCell biologyChemistryProgrammed cell deathCell growthSignal transductionKinaseCellCancer cellBiologyReceptorCancerBiochemistryGeneticsPhytochemistry and biological activity of medicinal plantsAdvanced Glycation End Products researchFlavonoids in Medical Research