Ultrasensitive determination of α-glucosidase activity using CoOOH nanozymes and its application to inhibitor screening
Demiao Ma, Jia Ge, Ang Wang, Jingxian Li, Hongfen Yang, Wenlei Zhai, Ren Cai
Abstract
. Furthermore, the designed sensing platform exhibits favorable applicability for the α-glucosidase (α-Glu) activity assay in real samples. Meanwhile, this method can be expanded to study the inhibitors of α-Glu. Finally, the as-proposed method combined with a smartphone would be a color recognizer, which was successfully applied for the determination of α-Glu activity in human serum samples.
Topics & Concepts
Combinatorial chemistryGlucose oxidaseNanotechnologyChemistryMaterials scienceBiosensorAdvanced Nanomaterials in CatalysisAdvanced biosensing and bioanalysis techniquesElectrochemical sensors and biosensors