A near-infrared light-activatable Ru(<scp>ii</scp>)-coumarin photosensitizer active under hypoxic conditions
Enrique Ortega, Anna Rovira, Marta López‐Corrales, Alba Hernández-García, Francisco J. Ballester, E. Izquierdo, Mireia Jordà‐Redondo, Manel Bosch, Santi Nonell, María Dolores Santana, José Ruiz, Vicente Marchán, Gilles Gasser
Abstract
). The induction of ROS-mediated cancer cell death upon low-energy wavelength irradiation along with the low dark toxicity exerted by this Ru(ii)-coumarin conjugate could circumvent tissue penetration issues while alleviating the hypoxia limitation of PDT. As such, this strategy could pave the way to the development of novel NIR- and hypoxia-active Ru(ii)-based theragnostic PSs fuelled by the conjugation of tunable, low molecular-weight COUPY fluorophores.
Topics & Concepts
PhotosensitizerPhotodynamic therapySinglet oxygenConjugatePhotochemistryChemistryReactive oxygen speciesCoumarinTumor hypoxiaBiophysicsOxygenBiochemistryRadiation therapyOrganic chemistryMedicineBiologyInternal medicineMathematicsMathematical analysisNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPhotodynamic Therapy Research Studies