Gastrointestinal Chlamydia-Induced CD8 <sup>+</sup> T Cells Promote Chlamydial Pathogenicity in the Female Upper Genital Tract
Qi Tian, Zengzi Zhou, Luying Wang, Xin Sun, Bernard P. Arulanandam, Dabao Xu, Min Xue, Guangming Zhong
Abstract
T cells induced by gastrointestinal Chlamydia are both necessary and sufficient for promoting hydrosalpinx in the genital tract. The study has laid a foundation for further revealing the mechanisms by which Chlamydia-induced T lymphocyte responses (as a 2nd hit) promote hydrosalpinx in mice with genital Chlamydia-triggered tubal injury (as a 1st hit), a continuing effort in testing the two-hit hypothesis as a chlamydial pathogenic mechanism.
Topics & Concepts
ChlamydiaHydrosalpinxBiologyChlamydia trachomatisImmunologyGastrointestinal tractMicrobiologySex organVirologyInfertilityGeneticsPregnancyBiochemistryGenital Health and DiseaseReproductive tract infections researchPelvic floor disorders treatments