Peptoid-based reprogrammable template for cell-permeable inhibitors of protein–protein interactions
Yasuhiro Fukuda, Marin Yokomine, Daisuke Kuroda, Kouhei Tsumoto, Jumpei Morimoto, Shinsuke Sando
Abstract
A peptoid-based modular approach using oligo( N -substituted alanine) as a reprogrammable template enables independent optimization of N -substituents and facile development of cell-permeable inhibitors of protein–protein interactions.
Topics & Concepts
PeptoidChemistryCombinatorial chemistryProtein–protein interactionComputational biologyPeptideBiochemistryBiologyChemical Synthesis and AnalysisMonoclonal and Polyclonal Antibodies ResearchClick Chemistry and Applications