Multi-analyte sensing strategies towards wearable and intelligent devices
Yu Huang, Cihui Luo, Fan Xia, Yanlin Song, Lei Jiang, Fengyu Li
Abstract
, they are convenient, rapid, sensitive and have high-throughput for multi-analyte identification in food safety, clinical diagnoses, and environmental monitoring. Besides traditional molecular design and recognition mechanisms, materials with micro/nano structures also contribute to strong signals, sensitive responses, and novel properties. In this review, through a new perspective of signal amplification for responsive discrimination, we summarize progress in developing sensing arrays based on diverse micro/nanomaterials and their integrated devices for multi-analyte discrimination. An overview of strategies for constructing sensing arrays through various micro or nano building blocks, including 0D nanoparticle assembly and modification, 1D nanowires and fibers, 2D graphene and textiles, is schematized. Then, portable and wearable devices integrating colorimetric sensors or flexible electrochemical electrodes with the newest microelectronic units and circuit boards are presented. Meanwhile, the latest artificial intelligence (AI) algorithms are introduced for massive data analysis in complex biological and environmental systems. With future developments in facile and accurate discrimination for multi-analyte research, extended applications will gear up in various fields.