Host–commensal interaction promotes health and lifespan in Caenorhabditis elegans through the activation of HLH-30/TFEB-mediated autophagy
Miroslav Dinić, Marija Herholz, Uroš Kačarević, Dušan Radojević, Katarina Novović, Jelena Đokić, Aleksandra Trifunović, Nataša Golić
Abstract
. Moreover, we observed that BGHV110 partially decreased the content of lipid droplets in an HLH-30-dependent manner and, at the same time, slightly increased mitochondrial activity. In summary, this study demonstrates that specific factors from commensal bacteria can be used to exploit HLH-30/TFEB-mediated autophagy in order to promote longevity and fitness of the host.
Topics & Concepts
Caenorhabditis elegansAutophagyTFEBBiologyLongevityCommensalismHost (biology)Cell biologyHomeostasisMutantCaenorhabditisBacteriaGeneticsGeneApoptosisGenetics, Aging, and Longevity in Model OrganismsGut microbiota and healthTryptophan and brain disorders