Analysis of mRNA‑lncRNA and mRNA‑lncRNA-pathway co‑expression networks based on WGCNA in developing pediatric sepsis
Xiaojuan Zhang, Yuqing Cui, Xianfei Ding, Shaohua Liu, Bing Han, Xiaoguang Duan, Haibo Zhang, Tongwen Sun
Abstract
: mRNA: messenger RNA; lncRNA: long noncoding RNAs; GEO: Gene Expression Omnibus; WGCNA: weighted gene co-expression network analysis; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; SIRS: systemic inflammatory response syndrome; TOM: topological overlap measure; BP: biological process; MF: molecular function; CC: cellular component; ROC: receiver operating characteristic curve; AUC: area under curve; MAPK14: Mitogen-activated protein kinase 14; ALI: acute lung injury; ITGAM: Integrin subunit alpha M; HK3: Hexokinase 3; LPS: lipopolysaccharide; 5-LO: 5-lipoxygenase; LTs: leukotrienes; LTB4R: leukotriene B4 receptor.
Topics & Concepts
KEGGBiologyGeneComputational biologyGene expressionMessenger RNARegulation of gene expressionBioinformaticsGeneticsGene ontologyATP Synthase and ATPases ResearchPeroxisome Proliferator-Activated ReceptorsMetabolomics and Mass Spectrometry Studies