Targeted NIR-triggered doxorubicin release using carbon dots–poly(ethylene glycol)–folate conjugates for breast cancer treatment
Paola Varvarà, Nicolò Mauro, Gennara Cavallaro
Abstract
studies on BC cells MCF-7 and MDA-MB-231 demonstrated NIR-enhanced antitumor efficacy, providing the opportunity to realize selective and remote-controlled synergistic therapy. Furthermore, uptake investigations highlighted the imaging potential of CDs and efficient internalization of doxorubicin, emphasizing FA's role in receptor-mediated specific targeting. Data suggest that CDs-bAPAE-PEG-FA/Dox could perform efficient image-guided and selective BC therapy, enhancing the therapeutic outcomes.
Topics & Concepts
ConjugateDoxorubicinEthylene glycolChemistryBreast cancerFolic acidFolate receptorNanotechnologyCombinatorial chemistryMaterials sciencePharmacologyCancerMedicineChemotherapyCancer cellOrganic chemistryInternal medicineMathematicsMathematical analysisCarbon and Quantum Dots ApplicationsGraphene and Nanomaterials ApplicationsNanoplatforms for cancer theranostics