Selectively attacking tumor cells of Ru/Ir–arene complexes based on meclofenamic acid <i>via</i> cyclooxygenase-2 inhibition
Yuanlei Huang, Mengdi Lv, Binglian Guo, Guojing Hu, Yong Qian, Zhi Su, Xuling Xue, Hong‐Ke Liu
Abstract
. These findings demonstrated that MA-bpy-Ru was capable of intervening in inflammatory processes and showed the potential of MA-bpy-Ru to act as a selective anticancer agent, thus presenting a new mechanism of action for metal-arene complexes.
Topics & Concepts
CyclooxygenaseCytotoxicityChemistryAutophagyApoptosisCell biologyCancer researchPharmacologyStereochemistryBiochemistryEnzymeIn vitroBiologyInflammatory mediators and NSAID effectsClick Chemistry and ApplicationsMetal complexes synthesis and properties