Deletion of mucin 2 induces colitis with concomitant metabolic abnormalities in mice
Jiayu Ye, Natasha Haskey, Hansika Dadlani, Hatem Zubaidi, Jacqueline A. Barnett, Sanjoy Ghosh, Deanna L. Gibson
Abstract
This study discloses the impaired systemic energy metabolism in a classic colitis murine model (Muc2 −/− knock-out model). Investigating the interaction between colitis and metabolic disorders helps to extend our knowledge on deciphering inflammatory bowel disease-associated comorbidities and provides new insight into clinical treatment.
Topics & Concepts
MucinConcomitantColitisMedicinePathologyInternal medicineHelicobacter pylori-related gastroenterology studiesGut microbiota and healthDigestive system and related health