<i>Mycoplasma pneumoniae</i> Macrolide Resistance and MLVA Typing in Children in Beijing, China, in 2016: Is It Relevant?
Hai Wei Dou, Xiu Jun Tian, De Li Xin, Ran Wei, Wei Zhou, Wang Hong, Xuan Qin, Jun Yan Shao, Bao Ping Xu, Ge Li, Da Wei Shi
Abstract
OBJECTIVE: of Beijing in 2016 in pediatric patients. METHODS: . RESULTS: in children in Beijing was 40%, and the macrolide resistance rate was 66%. The A2063G mutation in the 23S rRNA V region is the dominant mutation (137/146, 93.84%), whereas the A2064G mutation is rare (9/146, 6.16%). Seventy-three samples were typed successfully by MLVA typing, including 86.3% (63/73) were MLVA type 4-5-7-2, and 13.7% (10/73) were MLVA type 3-5-6-2. No other types were found. No strains were resistant to levofloxacin or tetracycline. CONCLUSION: .
Topics & Concepts
Multiple Loci VNTR Analysis23S ribosomal RNAMicrobiologyMycoplasma pneumoniaeVariable number tandem repeatBiologyTypingVirologyGeneticsMedicineGenotypeGeneRNAInternal medicinePneumoniaRibosomePneumonia and Respiratory InfectionsAntibiotics Pharmacokinetics and EfficacyMicrobial infections and disease research