Uncoupling Thrombosis and Hemostasis by Inhibiting Factor XI
Dominick J. Angiolillo, Davide Capodanno
Abstract
This editorial describes the science behind a clinical trial reported by Ruff et al. in which a monoclonal antibody targeting factors XI and XIa was evaluated for its effects on bleeding events in patients with atrial fibrillation.
Topics & Concepts
HemostasisThrombosisMedicineCardiologyInternal medicineCoagulation, Bradykinin, Polyphosphates, and AngioedemaBlood Coagulation and Thrombosis MechanismsMast cells and histamine