Daily Monitoring of D-Dimer Allows Outcomes Prediction in COVID-19
David M. Smadja, Olivier Bory, Jean‐Luc Diehl, Alexis Mareau, Nicolas Gendron, Anne‐Sophie Jannot, Richard Chocron
Abstract
) is associated with a prothrombotic phenotype, and D-dimer level at admission is a prognostic factor. 1-6 Some meta-analyses have tried to predict the outcomes of patients with COVID-19, including D-dimer levels, primarily those at hospital admission. 7 Most studies published to date have used baseline measurements or included participants with incomplete follow-up data. Few studies have been published about the dynamics of early changes in D-dimer levels in hospitalized patients with COVID-19 and their potential suitability for outcome assessment, that is, in-hospital mortality or disease worsening with intensive care unit (ICU) transfer. 8,9 However, D-dimer cutoff during follow-up to predict the outcomes and their involvement in daily clinical management of patients with COVID-19 is yet to be determined. n the retrospective study presented here, we monitored the daily D-dimer levels in a large cohort of 320 adult COVID-19-positive patients hospitalized at the Georges Pompidou European Hospital between February 1 and June 30, 2020 who underwent at least two D-dimer assessments during follow-up. We quantified D-dimer levels (Vidas D-dimers assay, Biomrieux, Marcy-Etoile, France; limit of quantification <45 ng/mL) during the first 9 days of hospitalization. The