Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO)
Kathryn H. Schmitz, Justin C. Brown, Melinda L. Irwin, Kim Robien, Jessica M. Scott, Nathan A. Berger, Bette J. Caan, Andrea Cercek, Tracy E. Crane, Scott R. Evans, Jennifer A. Ligibel, Jeffrey A. Meyerhardt, Tanya Agurs‐Collins, Karen Basen‐Engquist, Jennifer W. Bea, Sheng F. Cai, Brenda Cartmel, Vernon M. Chinchilli, Wendy Demark‐Wahnefried, Christina M. Dieli‐Conwright, Loretta DiPietro, Shawna E. Doerksen, Sharon L. Edelstein, Joanne W. Elena, William J. Evans, Leah M. Ferrucci, Julia Foldi, Sarah Freylersythe, Helena Furberg, Lee Jones, Ross L. Levine, Chaya S. Moskowitz, Cynthia Owusu, Frank J. Penedo, Borsika A. Rabin, Elena Ratner, Margaret Rosenzweig, Talya Salz, Tara Sanft, Matthew Schlumbrecht, Guillaume Spielmann, Cynthia A. Thomson, Ashley H. Tjaden, Martin R Weiser, Shengping Yang, Anthony F. Yu, Frank M. Perna, Bette Caan, Sydney Anderson, Harmenjit Bahia, Adrienne Castillo, Elizabeth Feliciano, Kristina Johnson, Michelle Ross, Erin Weltzein, Justin C Brown, Baylea Albarado, Stephanie Compton, Tamara Green, Ryan Nash, Phillip Nauta, Meredith Welch, Shengping Yang, Jeffrey A Meyerhardt, Christina M Dieli-Conwright, Danny Nguyen, Amalia Perez Pena, Guillaume Spielmann, Youyoung Kim, William J Evans, Jennifer W Bea, Robert M Blew, Tracy E Crane, Atif Bhatti, Reanna Clavon, Stefan Spee Erlandsen, Sarah Freylersythe, Kenna Hollander, Melissa Lopez-Pentecost, Frank J Penedo, LaShae Rolle, Paola Rossi, Matthew Schlumbrecht, Madalyn Wheeler, Melinda L Irwin, Anlan Cao, Brenda Cartmel, Leah M Ferrucci, Linda Gottlieb, Maura Harrigan, Fang-Yong Li, Courtney McGowan, Leah Puklin, Elena Ratner, Tara Sanft, Michelle Zupa, Nathan A Berger, Stephen Cerne, Carissa Mills, Sandy Conochan
Abstract
Chemotherapy treatment-related side effects are common and increase the risk of suboptimal outcomes. Exercise interventions during cancer treatment improve self-reported physical functioning, fatigue, anxiety, and depression, but it is unclear whether these interventions improve important clinical outcomes, such as chemotherapy relative dose intensity. The National Cancer Institute funded the Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO) Consortium to address this knowledge gap. This article describes the mechanisms hypothesized to underpin intervention effects on clinically relevant treatment outcomes, briefly outlines each project's distinct research aims, summarizes the scope and organizational structure of ENICTO, and provides an overview of the integrated common data elements used to pursue research questions collectively. In addition, the article includes a description of consortium-wide activities and broader research community opportunities for collaborative research. Findings from the ENICTO Consortium have the potential to accelerate a paradigm shift in oncology care such that patients with cancer could receive exercise and nutrition programming as the standard of care in tandem with chemotherapy to improve relative dose intensity for a curative outcome.