High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV
Gaoxingyu Huang, Dongliang Liu, Weipeng Wang, Qiurong Wu, Jiaofeng Chen, Xiaojing Pan, Huaizong Shen, Nieng Yan
Abstract
. The local secondary structural shift leads to contraction of the intracellular gate, closure of the fenestration on the interface of repeats I and IV, and rearrangement of the binding site for the fast inactivation motif.
Topics & Concepts
GatingTransition (genetics)Modulation (music)Nav1.5BiophysicsNanotechnologyChemistryNeuroscienceCell biologyPhysicsBiologyMaterials scienceGeneticsSodium channelGeneOrganic chemistrySodiumAcousticsATP Synthase and ATPases ResearchEnzyme Structure and FunctionHeat shock proteins research