Efficacy of Tegoprazan for Improving the Susceptibility of Antimicrobial Agents against Antibiotic-Resistant <i>Helicobacter pylori</i>
Jung Won Lee, Nayoung Kim, Ryoung Hee Nam, Jeong Eun Yu, Joo Hee Son, Sun Min Lee, Dong Ho Lee
Abstract
Background/Aims: efficacy of tegoprazan compared with that of vonoprazan. Methods: mutations, was also analyzed. Results: isolates improved after tegoprazan administration. Tegoprazan demonstrated more frequent susceptibility acquisition with metronidazole than with vonoprazan (20.6% vs 4.7%, p=0.014). However, there were no significant differences depending on the mutational status of each antimicrobial agent. Conclusions: , independent of acid suppression.
Topics & Concepts
Helicobacter pyloriClarithromycinMetronidazoleAmoxicillinAntimicrobialMedicineMicrobiologyAntibiotics23S ribosomal RNAAntibiotic resistanceAgar dilutionMinimum inhibitory concentrationBiologyInternal medicineBiochemistryGeneRibosomeRNAHelicobacter pylori-related gastroenterology studiesGastroesophageal reflux and treatmentsVeterinary medicine and infectious diseases