Ruthenium-Catalyzed Meta-Selective C-H Difluoromethylation of Phenol Derivatives
Xu Xu, Na Tao, Wei‐Tai Fan, Guangliang Tu, Jingyao Geng, Jingyu Zhang, Yingsheng Zhao
Abstract
With pyrimidine as the directing group, we achieved the meta-selective difluoromethylation of phenol derivatives using ruthenium as a catalyst. This synthetic scheme provided an efficient method for the syntheses of fluorine-containing phenol derivatives. A wide variety of phenol derivatives were well-suited, affording the corresponding products in moderate-to-good yields.
Topics & Concepts
PhenolRutheniumCatalysisChemistryCombinatorial chemistryOrganic chemistryPyrimidineStereochemistryFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsInorganic Fluorides and Related Compounds