Nonclinical Pharmacokinetics and Absorption, Distribution, Metabolism, and Excretion of Givosiran, the First Approved N-Acetylgalactosamine–Conjugated RNA Interference Therapeutic
Jing Li, Ju Liu, Xuemei Zhang, Valerie A. Clausen, Chris Tran, Michael Arciprete, Qianfan Wang, Carrie Rocca, Lihua Guan, Guodong Zhang, Diana Najarian, Yuanxin Xu, Pete Smith, Jing‐Tao Wu, Saeho Chong
Topics & Concepts
PharmacokineticsPharmacologyADMEChemistryCytochrome P450MetabolismExcretionDrug metabolismMetaboliteIsozymeRenal physiologyBiochemistryBiologyEnzymeRenal functionPorphyrin Metabolism and DisordersHeme Oxygenase-1 and Carbon MonoxidePorphyrin and Phthalocyanine Chemistry