A new strategy for the extrahepatic delivery of lipid-based nanomedicines: a protein corona-mediated selective targeting system based on an ionizable cationic lipid library
Mahmoud A. Younis, Yusuke Sato, Seigo Kimura, Hideyoshi Harashima
Abstract
Applying a molecularly diverse lipid library in the formulation of LNPs recruits endogenous proteins to generate a customized protein corona that directs LNPs to various extrahepatic organs, eliminating the need for external targeting ligands.
Topics & Concepts
Cationic polymerizationChemistryCorona (planetary geology)Delivery systemPharmacologyMedicineOrganic chemistryBiologyVenusAstrobiologyRNA Interference and Gene DeliveryDrug Transport and Resistance MechanismsNanoparticle-Based Drug Delivery