EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulation
Gao Guo, Ke Gong, Nicole A. Beckley, Yue Zhang, Xiaoyao Yang, Rati Chkheidze, Kimmo J. Hatanpaa, Tomás Garzón-Muvdi, Prasad Koduru, Arifa Nayab, Jennifer E. Jenks, Adwait Amod Sathe, Yan Liu, Chao Xing, Szu‐Yuan Wu, Cheng‐Ming Chiang, Bipasha Mukherjee, Sandeep Burma, Bryan Wohlfeld, Toral Patel, Bruce Mickey, Kalil G. Abdullah, Michael Youssef, Edward Pan, David E. Gerber, Shulan Tian, Jann N. Sarkaria, Samuel K. McBrayer, Dawen Zhao, Amyn A. Habib
Topics & Concepts
Epidermal growth factor receptorCancer researchOncogeneCyclin-dependent kinase 8Downregulation and upregulationSuppressorBiologyEGFR inhibitorsCancerSignal transductionCell biologyGeneCell cycleNotch signaling pathwayBiochemistryGeneticsGlioma Diagnosis and TreatmentCancer Mechanisms and TherapyNeurofibromatosis and Schwannoma Cases