Simultaneous determination of almonertinib and its active metabolite HAS-719 in human plasma by LC-MS/MS: Evaluation of pharmacokinetic interactions
Lu Liu, Le Yang, Wei Li, Xiaoyan Chen
Topics & Concepts
ChemistryProtein precipitationPharmacokineticsChromatographyAnalyteActive metaboliteTherapeutic drug monitoringSelected reaction monitoringMetaboliteElectrospray ionizationFormic acidMass spectrometryPharmacologyTandem mass spectrometryBiochemistryMedicineChronic Myeloid Leukemia TreatmentsPI3K/AKT/mTOR signaling in cancerChronic Lymphocytic Leukemia Research