Liverpool Epidemic Strain Isolates of Pseudomonas aeruginosa Display High Levels of Antimicrobial Resistance during Both Planktonic and Biofilm Growth
Mara C. Goodyear, Nicole E. Garnier, Roger C. Lévesque, Cezar M. Khursigara
Abstract
Pseudomonas aeruginosa is an opportunistic pathogen with high intrinsic antibiotic resistance. This resistance is typically increased in clinical isolates through adaptations to the host and production of small-colony variants (SCVs) and when P. aeruginosa forms biofilms, which are surface-attached communities that are protected by a self-produced matrix. Understanding the combination of SCVs, biofilm production, and the diversity of drug resistance phenotypes in clinical isolates can lead to improved treatments for P. aeruginosa infections.
Topics & Concepts
BiofilmPseudomonas aeruginosaMicrobiologyBiologyAntibioticsAntibiotic resistanceAntimicrobialMultidrug toleranceBacteriaDrug resistanceGeneticsBacterial biofilms and quorum sensingAntibiotic Resistance in BacteriaVibrio bacteria research studies