A 20-Year Research Overview: Quantitative Prediction of Hepatic Clearance Using the In Vitro-In Vivo Extrapolation Approach Based on Physiologically Based Pharmacokinetic Modeling and Extended Clearance Concept
Yuichi Sugiyama, Yasunori Aoki
Topics & Concepts
In vivoExtrapolationPharmacokineticsIn vitroPharmacologyMetabolic clearance rateChemistryPhysiologically based pharmacokinetic modellingBiologyBiochemistryMathematicsStatisticsBiotechnologyDrug Transport and Resistance MechanismsLiver Disease Diagnosis and TreatmentDrug-Induced Hepatotoxicity and Protection