Validation of genetic variants associated with metabolic dysfunction-associated fatty liver disease in an ethnic Chinese population
Guan Huei Lee, Wah Wah Phyo, Wai Mun Loo, Raymond Kwok, Taufique Ahmed, Asim Shabbir, Jimmy Bok Yan So, Calvin Jianyi Koh, Juanda Leo Hartono, Mark Muthiah, Kieron Lim, Poh Seng Tan, Yin Mei Lee, Seng Gee Lim, Yock Young Dan
Abstract
BACKGROUND: Genetic factors play an important role in the pathogenesis and development of metabolic dysfunction-associated fatty liver disease (MAFLD). AIM: To study the association of single nucleotide polymorphisms (SNPs), previously identified in Western populations, with the risk of MAFLD in a Singapore Chinese population and their interactions with environmental and medical risk factors. METHODS: Predesigned SNP Genotyping Assay. RESULTS: = 0.014) were associated with MAFLD (area under the receiver operating characteristic curve of 0.823). CONCLUSION: GG are independent predictors of MAFLD.