Obesity enriches for tumor protective microbial metabolites and treatment refractory cells to confer therapy resistance in PDAC
Kousik Kesh, Roberto Méndez, Beatriz Mateo-Victoriano, Vanessa T. Garrido, Brittany Durden, Vineet K. Gupta, Alfredo Oliveras Reyes, Nipun B. Merchant, Jashodeep Datta, Santanu Banerjee, Sulagna Banerjee
Abstract
treatment refractory tumor populations compared to control animals. These observations indicated that microbial metabolite Q accumulation in high fat diet-fed mice protected tumors from chemotherapy induced oxidative stress by upregulating PRDX1. This protection could be reversed by treatment with SAM. We conclude that relative concentration of SAM and queuosine in fecal samples of pancreatic cancer patients can be developed as a potential biomarker and therapeutic target in chemotherapy refractory pancreatic cancer.
Topics & Concepts
Pancreatic cancerChemotherapyMicrobiomeBiologyInsulin resistanceInternal medicineCancerGemcitabineColorectal cancerEndocrinologyCancer researchObesityGastroenterologyOncologyMedicineBioinformaticsPancreatic and Hepatic Oncology ResearchGut microbiota and healthEpigenetics and DNA Methylation