A nanoplatform for mild-temperature photothermal and type I & II photodynamic therapy in the NIR-II biowindow
Bing Lü, Zhecheng Zhang, Yuying Huang, Yuehua Zhang, Jin Wang, Yue Ding, Yang Wang, Yong Yao
Abstract
In the current work, we synthesized an A-D-A smallmolecule photosensitizer, denoted as DPTTIC, and a dual PEG-functionalized pillararene, denoted as WP5-8C-2PEG, and used them to construct novel DPTTIC nanoparticles (NPs) displaying NIR II absorption. Under 980 nm-wavelength laser irradiation, DPTTIC NPs performed well in mild-temperature photothermal and type I & II photodynamic anti-tumor therapy.
Topics & Concepts
Photothermal therapyPhotodynamic therapyChemistryNanotechnologyPhotochemistryMaterials scienceOrganic chemistryNanoplatforms for cancer theranosticsPhotoacoustic and Ultrasonic ImagingPhotodynamic Therapy Research Studies