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Prediction of maternal pharmacokinetics using physiologically based pharmacokinetic models: assessing the impact of the longitudinal changes in the activity of CYP1A2, CYP2D6 and CYP3A4 enzymes during pregnancy

Khaled Abduljalil, Amita Pansari, Masoud Jamei

2020Journal of Pharmacokinetics and Pharmacodynamics59 citationsDOI

Topics & Concepts

PharmacokineticsPhysiologically based pharmacokinetic modellingPharmacologyCYP3A4ChemistryCYP2D6CYP1A2PregnancyMedicineCytochrome P450EnzymeBiochemistryBiologyGeneticsPharmacogenetics and Drug MetabolismPregnancy and Medication ImpactPharmacological Effects and Toxicity Studies
Prediction of maternal pharmacokinetics using physiologically based pharmacokinetic models: assessing the impact of the longitudinal changes in the activity of CYP1A2, CYP2D6 and CYP3A4 enzymes during pregnancy | Litcius