Mild hypothermia alleviates oxygen−glucose deprivation/reperfusion-induced apoptosis by inhibiting ROS generation, improving mitochondrial dysfunction and regulating DNA damage repair pathway in PC12 cells
Tianen Zhou, Jierong Mo, Weigan Xu, Qiaohua Hu, Hongfeng Liu, Yue Fu, Jun Jiang
Topics & Concepts
Mitochondrial permeability transition poreApoptosisViability assayReactive oxygen speciesCytochrome cMitochondrionCell biologyBiologyLactate dehydrogenaseMolecular biologyChemistryPharmacologyProgrammed cell deathBiochemistryEnzymeThermal Regulation in MedicineCardiac Arrest and ResuscitationHeme Oxygenase-1 and Carbon Monoxide