Hippocampal gamma and sharp-wave ripple oscillations are altered in a Cntnap2 mouse model of autism spectrum disorder
Rosalia Paternò, Joseane Righes Marafiga, Harrison J. Ramsay, Tina Li, Kathryn A. Salvati, Scott C. Baraban
Abstract
mice show a reduction in hippocampal PV interneuron density, reduced inhibitory input to CA1 pyramidal cells, deficits in spatial discrimination ability, and frequency-dependent circuit changes within the hippocampus, including alterations in gamma oscillations, sharp-wave ripples, and theta-gamma modulation. Our findings highlight hippocampal involvement in ASD and implicate interneurons as a potential therapeutical target.
Topics & Concepts
Hippocampal formationNeuroscienceAutism spectrum disorderRippleAutismPhysicsAudiologyNuclear magnetic resonanceBiologyPsychologyMedicinePsychiatryQuantum mechanicsVoltageNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanismsGenetics and Neurodevelopmental Disorders