Palladium Catalyzed Dicarbonylation of α-Iodo-Substituted Alkylidenecyclopropanes: Synthesis of Carbamoyl Substituted Indenones
Lin Li, Xin‐Lian Liu, Jin-Yan Liang, Yong-Yu He, Ai‐Jun Ma, Wei-Feng Wang, Jin‐Bao Peng
Abstract
A palladium catalyzed dicarbonylation of α-iodo-substituted ACPs for the synthesis of carbamoyl substituted indenones has been developed. Two carbonyl groups were incorporated into the product with the cleavage of the proximal C-C bond of the ACPs. A broad range of carbamoyl substituted indenones were efficiently prepared in good to excellent yields.
Topics & Concepts
ChemistryPalladiumCatalysisCleavage (geology)Combinatorial chemistryBond cleavageMedicinal chemistryOrganic chemistryEngineeringFracture (geology)Geotechnical engineeringCyclopropane Reaction MechanismsCatalytic Alkyne ReactionsCatalytic C–H Functionalization Methods